Risks Associated With CFD

Despite low fibrinogen levels, CFD carries a notable thrombotic risk, including venous and arterial events, due to loss of fibrin’s antithrombin-like properties and abnormal clot architecture.1

CFD Considerations

Surgical interventions and pregnancy require meticulous planning, as inadequate fibrinogen replacement can result in catastrophic bleeding, whereas excessive supplementation may exacerbate thrombosis.1

These challenges underscore the need for individualized management strategies and reliable fibrinogen replacement to maintain hemostatic balance.1,2

How CFD can present in patients

Afibrinogenemia typically manifests as hemorrhage in the neonatal period, with umbilical stump bleeding reported in approximately 85% of cases3

Individuals with hypofibrinogenemia (fibrinogen levels ≤ 150 mg/dL) are typically asymptomatic but may bleed more easily if injured or if another bleeding disorder is present4

Females with afibrinogenemia have reported menorrhagia, menometrorrhagia, and postpartum hemorrhage5

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Considerations for patients with CFD in a 
hospital setting

A discussion about the considerations for patients with CFD in a hospital setting and the importance of educating hospital staff about the condition.

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VIDEO

Patient education for CFD

Gain a better understanding of how to educate patients and their caregivers about recognizing and managing CFD.

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CFD can pose a significant risk for patients.2

Diagnosing CFD
Diagnosing CFD

Get more information about CFD, management options, and treatment advancements.

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References

  1. May JE, Wolberg AS, Lim MY. Disorders of fibrinogen and fibrinolysis. Hematol Oncol Clin North Am. 2021;35(6):1197-1217.
  2. Casini A. How I treat quantitative fibrinogen disorders. Blood. 2025;145(8):801-810.
  3. de Moerloose P, Neerman-Arbez M. Congenital fibrinogen disorders. Semin Thromb Hemost. 2009;35:356-366.
  4. Peyvandi F. Epidemiology and treatment of congenital fibrinogen deficiency. Thromb Res. 2012;130(S2):s7-s11.
  5. Acharya SS, DiMichele DM. Rare inherited disorders of fibrinogen. Haemophilia. 2008;14:1151-1158.